Anti-TBKBP1 Antibody [AB01/2C8]

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

TBKBP1

Applications

WB

Reactivity

Human

Formulation

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein G affinity chromatography of tissue culture supernatant.

Isotype

IgG1

Recommended dilutions

WB: 1:1,000

Molecular weight

80 kDa in HEK293 cell lysates

Protein Length

279

Clonă

AB01/2C8

Secvență

MESMFEDDISILTQEALGPSEVWLDSPGDPSLGGDMCSASHFALITAYGDIKERLGGLERENATLRRRLKVYEIKYPLISDFGEEHGFSLYEIKDGSLLEVEKVSLQQRLNQFQHELQKNKEQEEQLGEMIQAYEKLCVEKSDLETELREMRALVETHLRQICGLEQQLRQQQGLQDAAFSNLSPPPAPAPPCTDLDLHYLALRGGSGLSHAGWPGSTPSVSDLERRRLEEALEAAQGEARGAQLREEQLQAECERLQGELKQLQETRAQDLASNQSER

Imunogen

E. coli derived recombinant protein corresponding to amino acids 1-279 of human TBKBP1.

Aminoacizi

aa 1 - 279

Specificitate

This antibody recognises the protein SINTBAD, otherwise known as TANK-binding kinase 1-bindng protein 1 or TBK1-binding protein 1.SINTBAD acts as an adaptor protein and plays a role in antiviral innate responses by essentially binding to TBK1 and IKBKE. Interaction of these kinases induces phosphorylation and following activation of IRF-3 transcription factor thus leading to gene regulation for immune responses. There is evidence that show IKBKE and TBK1 are crucial oncogenes for activation of a number of signalling pathways in numerous tumours. In addition, SINTBAD protein is involved in the facilitation autophagy-initiating kinase ULK1 to control IL-15-induced autophagy in natural killer T cells. Mouse anti Human SINTBAD antibody detects a band of 80 kDa.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

• Fișă tehnică (PDF)se deschide pe site-ul producătorului