Anti-IRS2 Antibody [G01-8F7]

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

IRS2

Applications

WB

Reactivity

Human

Formulation

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein G affinity chromatography of tissue culture supernatant.

Isotype

IgG1

Recommended dilutions

WB: 1:500

Molecular weight

180 kDa in THP-1 cell lysates

Protein Length

304

Clonă

G01-8F7

Secvență

PPAPGELYRLPPASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVAATPPQPIAAPPKPEAARVASPTSGVKRLSLMEQVSGVEAFLQASQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGVGVGPGGGDEPPTSPRQLQPAPPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGLNYIAIDVREEPGLPPQPQPPPPPLPQPGDKSSWGRTRSLGGLISAVGVGSTGGGCGGPGPGALPPANTYASIDFLSHHLKEATIVKE

Imunogen

E. coli derived recombinant protein corresponding to amino acids 1035-1338 of human IRS2.

Aminoacizi

aa 1035 - 1338

Specificitate

This antibody recognises insulin receptor substrate 2.IRS2 is a cytoplasmic signaling molecule. IRS2 along with IRS1, is a key target of the insulin receptor tyrosine kinase. Serine/threonine phosphorylation of IRS2 has been shown to regulate insulin sensitivity, suggesting that it is required for hormonal control of metabolism. Reduced expression of IRS2 has been shown to result in type 2 diabetes and reduced brain mass in mice (Lin et al. 2004, Schubert et al. 2003)

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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