Anti-GNB1 Antibody [AB04/2E5]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

GNB1

Applications

WB

Reactivity

Human, Mouse, Rat

Formulation

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein G affinity chromatography of tissue culture supernatant.

Isotype

IgG2b

Recommended dilutions

WB: 1:10,000

Protein Length

340

Clonă

AB04/2E5

Secvență

MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Imunogen

E. coli derived recombinant protein corresponding to amino acids 1-340 of human GNB1.

Aminoacizi

aa 1 - 340

Specificitate

This antibody recognises guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, otherwise known as transducin beta chain 1.GNB1 forms heterotrimeric complexes with G protein subunits a and ?. Mutations in the gene encoding GNB1 result in GNB1 syndrome; with symptoms including developmental delay, hypotonia and epilepsy (Steinrücke et al. 2016). The targeting of GNB1 with microRNA miR-545-3P has been shown to inhibit the progression of some cancers including colon cancer and retinoblastoma (Hu et al. 2022; Tang et al. 2022). Mouse anti Human GNB1 antibody detects a band of 33 kDa.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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