Anti-SHC3 / SHCC Antibody [AB04/6H9-5]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

SHC3 / SHCC

Applications

WB

Reactivity

Human, Mouse, Rat

Formulation

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein G affinity chromatography of tissue culture supernatant.

Isotype

IgG2b

Recommended dilutions

WB: 1:1,000

Molecular weight

65 kDa in HeLa cell lysates

Protein Length

498

Clonă

AB04/6H9-5

Secvență

MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDGPGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPAMSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAET

Imunogen

E. coli derived recombinant protein corresponding to amino acids 1-498 of human SHC3.

Aminoacizi

aa 1 - 498

Specificitate

This antibody recognises SHC-transforming protein 3, also known as protein Rai.SHC3 is an adaptor protein belonging to the SHC family and is thought to play a role in cell differentiation and cell survival. Downregulation of SHC3 results in aberrant levels of hypoxic signaling, inflammatory responses and apoptosis. SHC3 is overexpressed in a number of different cancers (Magrassi et al. 2005, Miyake et al. 2005, De Falco et al. 2005, Liu et al. 2018).

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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