Anti-FES Antibody [AB04-4F6]

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

FES

Applications

WB

Reactivity

Human

Formulation

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein G affinity chromatography of tissue culture supernatant.

Isotype

IgG1

Recommended dilutions

WB: 1:1,000

Molecular weight

94 kDa in THP-1 cell lysate

Protein Length

459

Clonă

AB04-4F6

Secvență

MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQL

Imunogen

E. coli derived recombinant protein corresponding to amino acids 1-459 of human FES.

Aminoacizi

aa 1 - 459

Specificitate

This antibody recognises tyrosine-protein kinase FES/FPS, otherwise known as feline sarcoma/fujinami avian sarcoma oncogene homolog, proto-oncogene c-FES, proto-oncogene c-FPS or p93c-FES.FES is one of two members of a unique family of cytoplasmic protein tyrosine kinases, alongside tyrosine-protein kinase FER. This family of kinases contains a central src homology-2 (SH2) domain and a COOH-terminal tyrosine kinase catalytic domain and are distinct from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of NH2-terminal FER/CIP4 homology and coiled-coil domains. Studies initially suggested that mutations in FES contribute to the development of some cancers. However, more recent research has shown that FES may act a tumor suppressor in colorectal cancer.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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