Anti-SHC Antibody [K02/12E8]

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

SHC

Applications

WB, IP

Reactivity

Human, Mouse, Rat

Formulation

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein G affinity chromatography of tissue culture supernatant.

Isotype

IgG1

Recommended dilutions

IP: 2.5 µg, WB: 1:500 - 1:1,000

Molecular weight

67 kDa in HeLa cell lysates

Protein Length

110

Clonă

K02/12E8

Secvență

MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQD

Imunogen

E. coli derived recombinant protein corresponding to amino acids 1-110 of human SHC1 p66.

Aminoacizi

aa 1 - 110

Specificitate

This antibody recognises SRC homology 2 domain-containing transforming protein C1 isoform p66, also known as SHC-transforming protein 3 isoform p66 or SHC-transforming protein A isoform p66.SHC1 is a ubiquitously-expressed signaling adapter, linking activated growth factor receptors to signaling pathways. Importantly, EGFR signaling is mediated by phosphorylation and interactions of SHC1 protein, defining output from the EGF R pathway. SHC1 exists as three functionally-distinct isoforms with molecular weights 46 kDa, 52 kDa and 66 kDa. These isoforms are encoded from the same gene, sharing a common structure and each possessing several phosphorylation sites. SHC1 plays an oncogenic role in several cancer types. Isoforms of SHC1 may have distinct roles in disease.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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