Anti-NFkB Inducing Kinase NIK Antibody [EF02-1H3]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

NFkB Inducing Kinase NIK

Applications

WB

Reactivity

Human, Mouse, Rat

Formulation

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein G affinity chromatography of tissue culture supernatant.

Isotype

IgG1

Recommended dilutions

WB: 1:1,000

Molecular weight

104 kDa in Jurkat cell lysates. Multiple bands are observed when using Mouse Anti-Human MAP3K14 Antibody in Western Blotting due to the poly-ubiquitination of MAP3K14 that can either stabilize and activate it or induce its degradation by the proteasome.

Protein Length

392

Clonă

EF02-1H3

Secvență

IPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPEPPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLNSLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSSSWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFSLVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP

Imunogen

E. coli derived recombinant protein corresponding to amino acids 556-947 of human MAP3K14.

Aminoacizi

aa 556 - 947

Specificitate

This antibody recognises mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase (NIK).MAP3K14 is a lymphotoxin beta-activated kinase that plays a role in the activation of NF-kappa-B and its transcriptional activity by promoting proteolytic processing of NFKB2/P100. Overexpression of MAP3K14 is seen in inflammatory diseases, metabolic abnormalities, and the formation and progression of cancer. Loss of MAP3K14 causes severe immunological deficiencies.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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