Anti-NLRX1 Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

NLRX1

Applications

WB

Reactivity

Human

Formulation

Supplied in TRIS Buffered Saline, 0.5% BSA and 0.02% Sodium Azide.

Conjugate

Unconjugated

Host

Goat

Clonality

Polyclonal

Product form

Liquid

Concentration

500 µg/ml

Isotype

IgG

Recommended dilutions

WB: 1 µg/ml - 3 µg/ml

Molecular weight

Approximately 100 kDa in cell lysates

Secvență

C-NFSGETLDSTDPSN

Imunogen

A peptide sequence of C-NFSGETLDSTDPSN from the internal region of the protein sequence according to NP_078894.2; NP_733840.1.

Specificitate

This antibody recognises NLR family member X1 (NLRX1), also known as caterpiller protein 11.3, NOD26, NOD5, and NOD9.NLRX1 is a member of the NLR family of pattern recognition receptors (PRRs), but is an atypical member due to its structure. For example, it appears to be the only PRR family member with the ability to localize to mitochondria. However, NLRX1 appears to be ubituitously expressed in human cells, and appears to have different functions depending on cell type. NLRX1 appears to be a negative regulator of immune signaling during microbial infection, cancer, and autoimmune disease. Consistent with mitochondrial localization, NLRX1 regulates the function of mitochondria during apoptosis and injury in the presence of TNF-alpha.

Storage

Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Documentație

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