Anti-BAP1 Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

100µl

Țintă

BAP1

Applications

WB

Reactivity

Human, Mouse

Formulation

Supplied in Phosphate Buffered Saline with 0.035% Sodium Azide and 30% Glycerol.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Polyclonal

Product form

Liquid

Concentration

Lot Specific

Isotype

IgG

Recommended dilutions

WB: 1:500-1:2,000

Imunogen

A peptide derived from within the C-terminus of human BAP1.

Specificitate

This antibody recognises bAP1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), also known as BRCA1-associated protein 1 or cerebral protein 6.BAP1 localizes to the nucleus where it acts as a deubiquitinase due to its ubiquitin carboxy-terminal hydrolase (UCH) domain. BAP1 is a member of the polycomb-group proteins (PcGs). PcGs are a group of highly conserved transcriptional repressors required for long-term silencing of genes that regulate various processes including cell fate determination, and stem cell pluripotency (Gaytán de Ayala Alonso et al. 2007). BAP1 functions as a tumor suppressor and mutations in the BAP1 gene may be linked to the development of a number of different cancers including malignant mesothelioma.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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