Anti-AMPK alpha 2 Antibody

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

AMPK alpha 2

Applications

WB, ELISA 

Reactivity

Human, Dog, Bovine, Mouse, Rat, Pig

Formulation

Supplied in TRIS Buffered Saline, 0.5% BSA and 0.02% Sodium Azide.

Conjugate

Unconjugated

Host

Goat

Clonality

Polyclonal

Product form

Liquid

Concentration

500 µg/ml

Isotype

IgG

Recommended dilutions

ELISA: 1:16,000, WB: 1 - 3.0 µg/ml

Molecular weight

Approximately 65 kDa in Human heart and liver cell lysates.

Secvență

CPLDALNTTKP

Imunogen

Synthetic peptide sequence CPLDALNTTKP from the internal region of AMPK alpha 2 (NP_006243.2).

Specificitate

This antibody recognises human 5'-AMP-activated protein kinase catalytic subunit alpha-2, also known as AMPK alpha 2, ACACA kinase, Acetyl-CoA carboxylase kinase or Hydroxymethylglutaryl-CoA reductase kinase, encoded by the PRKAA2 gene. AMPK alpha 2 is a a Serine/threonine-protein kinase and the catalytic subunit of the AMP-activated protein kinase (AMPK), a central metabolic sensor, essential for the regulation of fatty acid and cholesterol synthesis, in response to fluctuations in nutrient and intracellular energy levels.AMPK has been implicated as a suppressor of cell proliferation of both normal and malignant cells. AMPK binding to the PS domain of ULK1, is essential for ULK1-mediated autophagy , and that the phosphorylation of raptor by AMPK, plays an important role in autophagy induction.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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