Anti-DPF2 / REQ Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

DPF2/REQ

Applications

WB, IHC-P

Reactivity

Human

Formulation

Supplied in TRIS Buffered Saline, 0.5% BSA and 0.02% Sodium Azide.

Conjugate

Unconjugated

Host

Goat

Clonality

Polyclonal

Product form

Liquid

Concentration

500 µg/ml

Isotype

IgG

Recommended dilutions

IHC-P: 5 µg/ml, WB: 1 µg/ml - 3 µg/ml

Molecular weight

Approximately 50 kDa and 48 kDa in cell lysates

Secvență

C-QPPTPVSQRSEEQKS

Imunogen

A peptide sequence of C-QPPTPVSQRSEEQKS from the internal region of the protein sequence according to NP_006259.1.

Specificitate

This antibody recognises zinc finger protein ubi-d4, also known as BAF45D, REQ, and UBID4.DPF2 is a plant homeodomain (PHD) finger protein with roles in apoptosis, noncanonical NF-kappaB signaling and oncogenesis. It acts as an adaptor protein, linking RelB/p52 with the SWI/SNF chromatin-remodeling complex. In human tissues, DPF2 is ubiquitously expressed but was discovered as being required for apoptosis in myeloid cells. Furthermore, this protein appears to play a role in inhibiting the differentiation of myeloid cells. DPF2 is associated with multiple human cancers including cervical cancer and acute myelogenous leukemia (AML). DPF2 also appears to play a role in influenza infection, with knockdown of DPF2 leading to decreased infectivity of the virus.

Storage

Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Documentație

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