Anti-Dynamin (phospho Ser774) Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

100µl

Țintă

Dynamin

Applications

WB, IHC-Fr, IF

Reactivity

Rat, Human, Monkey, Bovine, Chicken, Mouse, Dog

Formulation

Supplied in 10mM HEPES, pH 7.5, with 0.01% BSA, 50% Glycerol, and 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Sheep

Clonality

Polyclonal

Product form

Liquid

Concentration

Lot Specific

Isotype

IgG

Recommended dilutions

WB: 1:1,000

Molecular weight

Approximately 95 kDa in rat hippocampus lysates.

Imunogen

Synthetic phosphopeptide corresponding to an amino acid sequence within dynamin which includes phosphorylated Ser774.

Specificitate

This antibody recognises dynamin, also known as B-dynamin and D100, when phosphorylated at serine 774.Dynamin is a phosphoprotein expressed at nerve terminals, which plays an important role in the regulation of synaptic vesicle endocytosis. Cyclin dependent protein kinase 5 (cdk5) has been shown to phosphorylate serine 774 and 778 in vivo. Dephosphorylation of these residues is essential for endocytosis of synaptic vesicles.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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