Anti-Dopamine Transporter Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

100µl

Țintă

Dopamine Transporter

Applications

WB, IHC-Fr

Reactivity

Human, Monkey, Mouse

Formulation

Supplied in 10mM HEPES, pH 7.5, with 150mM NaCl, 0.01% BSA, 50% Glycerol, and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Polyclonal

Product form

Liquid

Concentration

Lot Specific

Isotype

IgG

Recommended dilutions

IHC-Fr: 1:1,000, WB: 1:1,000

Molecular weight

Approximately 88 kDa in human caudate cell lysates.

Imunogen

Synthetic peptide corresponding to the C-terminus of human dopamine transporter, conjugated to Keyhole Limpet Haemocyanin.

Specificitate

This antibody recognises an epitope within the C-terminal region of dopamine transporter (DAT), also known as solute carrier family 6.DAT is principally expressed in the presynaptic membrane of dopaminergic nerve terminals, where it mediates the rapid removal of dopamine from the synaptic cleft after neuronal stimulation. As such, DAT plays an important role in regulating the availability of dopamine in the synaptic cleft and thus in modulating the physiological functions of dopamine.The reuptake of dopamine by DAT is inhibited by psychostimulants such as cocaine and amphetamine.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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