Anti-AATF / DED Antibody [1B2D8]

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

AATF/DED

Applications

IF, WB

Reactivity

Mouse, Human

Formulation

Supplied in Phosphate Buffered Saline with 0.035% Sodium Azide and 30% Glycerol.

Conjugate

Unconjugated

Host

Rat

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein A affinity chromatography of tissue culture supernatant.

Isotype

IgG2a

Recommended dilutions

IF: 1:100 - 1:500, WB: 2 µg/ml - 4 µg/ml

Protein Length

39

Clonă

1B2D8

Secvență

MAAPQPLALQLEQLLNPRPREADPEADPEEATRARVIDR

Imunogen

A peptide corresponding to amino acids 1-39 of mouse AATF (apoptosis-antagonizing transcription factor).

Aminoacizi

aa 1 - 39

Specificitate

This antibody recognises apoptosis-antagonizing transcription factor, also known as Rb-binding protein che-1.AATF was first identified as an RNA pol II – interacting factor. AATF is a protein encoded by the AATF gene. AATF mediates cellular responses and promotes cell proliferation and survival by inducing autophagy, DNA repair, and cell cycle arrest and inhibiting apoptosis. DNA damage leads to phosphorylation of AATF at tyrosine 366 by the MAP kinase-activated protein kinase 2 (MK2) (Höpker et al. 2012). Rat anti Mouse AATF antibody detects a band of 80 kDa.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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