Anti-PRMT2 / HMT1 Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

100µl

Țintă

PRMT2/HMT1

Applications

IF, WB

Reactivity

Human

Formulation

Supplied in Phosphate Buffered Saline with 0.035% Sodium Azide and 30% Glycerol.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Polyclonal

Product form

Liquid

Concentration

Lot Specific

Isotype

IgG

Recommended dilutions

IF: 1:2,000, WB: 1:500 - 1:2500

Imunogen

A peptide derived from within the N-terminus of human PRMT2.

Specificitate

This antibody recognises protein arginine N-methyltransferase 2.PRMT2 methylates arginyl residues in proteins such as STAT3, FBL, histone H4 and functions as a coactivator of androgen receptor (AR)-mediated and estrogen receptor (ER)-mediated transactivation (Qi et al. 2002, Meyer et al. 2007). PRMT2 may inhibit NF-kappa-B transcription and promote apoptosis involved in growth regulation. In humans, the C-terminal domain of pol II (CTD) comprises 52 repeats of the consensus heptapeptide Tyr1/Ser2/Pro3/Thr4/Ser5/Pro6/Ser7 that is phosphorylated by several kinases during transcription.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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