Anti-CENPA (phospho Ser18) Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

100µl

Țintă

CENPA

Applications

IF, WB

Reactivity

Human

Formulation

Supplied in Phosphate Buffered Saline with 0.035% Sodium Azide and 30% Glycerol.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Polyclonal

Product form

Liquid

Concentration

Lot Specific

Isotype

IgG

Recommended dilutions

IF: 1:100, WB: 1:100 - 1:500

Imunogen

Synthetic peptide of phosphorylated serine 16 and 18 of human CENP-A.

Specificitate

This antibody recognises centromere protein A when phosphorylated at serine 18.CENP-A is a histone H3 variant which replaces one or both canonical H3 histones in a subset of nucleosomes within centromeric chromatin and epigenetically determines the position of the centromere on each chromosome, and where kinetochore assembly and sister chromatid cohesion occurs during mitosis. CENP-A has been shown to interact directly with the inner kinetochore through CENP-C and CENP-N. This interaction allows microtubules to accurately segregate chromosomes during mitosis. Phosphorylation of CENP-A on serine 18 is thought to play an important role in the segregation of chromosomes during mitosis. Rabbit anti human CENP-A (pSer18) antibody shows minimal cross-reactivity with CENP-A that has been phosphorylated at serine 16.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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