Anti-Cdk8 Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

100µl

Țintă

Cdk8

Applications

ChIP, WB

Reactivity

Human, Mouse

Formulation

Supplied in Phosphate Buffered Saline with 0.035% Sodium Azide and 30% Glycerol.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Polyclonal

Product form

Liquid

Concentration

Lot Specific

Isotype

IgG

Recommended dilutions

ChIP: 10 µl per ChIP, WB: 1:500 - 1:1500

Imunogen

A peptide derived from within the C-terminus of human CDK8.

Specificitate

This antibody recognises cell division protein kinase 8, also known as cell division protein kinase 8 or mediator complex subunit CDK8.CDK8 is a 53 kDa is a member of the cyclin-dependent protein kinase (CDK) family involved in transcriptional regulation via interaction with the mediator complex. CDK8 regulates the activity of several transcription factors via its kinase activity, including STAT1. CDK8 is also able to inhibit transcriptional activation by influencing the turnover of subunits in the mediator complex tail module and mediating the binding of RNA polymerase II to the mediator complex. Expression of CDK8 may contribute to the development of a number of different types of cancer (Firestein et al. 2008, Donner et al. 2007).

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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