Anti-MDMX / MDM4 Antibody [AB01/4H9]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

MDMX / MDM4

Applications

WB

Reactivity

Human

Formulation

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein G affinity chromatography of tissue culture supernatant.

Isotype

IgG1

Recommended dilutions

WB: 1:1,000

Molecular weight

Approximately 70 kDa in HEK293 cell lysates.

Protein Length

490

Clonă

AB01/4H9

Secvență

MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA

Imunogen

E. coli derived recombinant protein corresponding to amino acids 1-490 of human MDM4..

Aminoacizi

aa 1 - 490

Specificitate

This antibody recognises protein MDM4 also known as p53-binding protein MDM4.MDM4 is comprised of four key domains, which include an N-terminus, an acidic region, a zinc region and a C-terminal RING. It is on this N-terminus whereby MDM4 binds to the major tumor suppressor p53. MDM4 is structurally similar to MDM2. Both proteins are involved in suppression of p53 activity and have been seen to increase in a number of cancers.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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