Anti-Integrin beta 2 Antibody [BAQ30A]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

Integrin beta 2

Applications

Flow Cytometry

Reactivity

Bovine, Goat, Sheep, Bison, Water Buffalo, Cat, Dog, Alpaca, Llama, Human

Formulation

Supplied in serum free tissue culture medium containing proprietary protein free supplement and 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

0.2µM sterile filtered.

Isotype

IgG1

Recommended dilutions

Flow Cytometry: Neat - 1:10, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl.

Clonă

BAQ30A

Imunogen

Cells from multiple species.

Specificitate

This antibody recognises bovine CD18 also known as ITGB2 or integrin beta-2. CD18 is a receptor for ICAM1, ICAM2, ICAM3, and ICAM4. It recognises the G-P-R motif in the fibrinogen alpha chain and is involved in leukocyte adhesion as well as transmigration of T cells and neutrophils. Different from other organisms, the signal peptide of ruminant CD18, the beta subunit, is not cleaved and remains intact on the mature CD18 molecule, leukotoxin from Pasteurella haemolytica binds to the intact signal peptide on ruminant leukocytes causing acute inflammation and lung damage. Holstein cattle harbor a mutation in CD18 causing bovine leukocyte adhesion deficiency (BLAD) syndrome with decreased expression of beta 2 integrins and lowered susceptibility to cytolysis in Pasteurella infections.

Storage

Store at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use.

Documentație

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