Recombinant Mouse M-CSF Protein

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Specificații

Brand

Antibodies

Mărime

10µg

Țintă

M-CSF

Applications

Functional Assays

Product form

Lyophilized

Concentration

100 µg/ml after reconstitution.

Purity

>98% (by SDS-PAGE and HPLC).

Reconstitution

Reconstitute with 100 µl of distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Gently mix after reconstitution.

Expression system

Escherichia coli

Nature

Recombinant

Protein species

Mouse

Endotoxin level

< 1 EU/µg

Specificitate

M-CSF (macrophage colony-stimulating factor) is a potent lineage restricted hematopoietic growth factor and member of the CSF family of hormone-like glycoproteins, which plays a key role in the regulation of cellular differentiation, proliferation, and the survival of blood monocytes, tissue macrophages and their progenitor cells. Along with sRANKL/CD254/OPGL, M-CSF is essential for osteoclastogenesis, acting through the tyrosine kinase receptor c-fms (colony stimulating factor 1 receptor). A genetic defect in M-CSF is responsible for osteopetrosis in mice (op/op), which are severely deficient in mature macrophages and have a restricted capacity for bone remodeling.

Storage

Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Documentație

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