Anti-Topoisomerase II alpha Antibody [TOP2A/6570R]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

Topoisomerase II alpha

Applications

WB, IHC-P

Reactivity

Human

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Monoclonal

Product form

Liquid

Concentration

200 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG

Recommended dilutions

WB: 2-4 µg/ml, IHC-P: 1-2 µg/ml

Molecular weight

170 kDa

Clonă

TOP2A/6570R

Imunogen

Recombinant fragment, around amino acids 1,352-1,493, of human Topoisomerase II alpha. The exact sequence is proprietary.

Specificitate

The topoisomerase II-α isoform is a 170kDa nuclear protein and plays an important role in DNA synthesis and RNA transcription, as well as chromosomal segregation during mitosis. Topoisomerase II-α is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells, and has been shown to be over-expressed in many human cancers. Decreased expression of Topoisomerase II-α is the predominant mechanism of resistance to several chemotherapeutic agents.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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