Anti-TNF alpha Antibody [TNF706 + P/T2]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

TNF Alpha

Applications

IHC-P

Reactivity

Human, Mouse, Rat, Rabbit, Feline, Canine, Zebrafish

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

200 µg/ml

Isotype

IgM

Recommended dilutions

IHC-P: 2-4 µg/ml

Molecular weight

17 kDa

Light chain

kappa

Clonă

TNF706 + P/T2

Imunogen

Clone TNF706: Recombinant N terminal fragment of human TNF alpha. Clone P/T2: Synthetic peptide corresponding to amino acids 115-130 of human TNF alpha.

Specificitate

TNF alpha is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17kDa band following SDS PAGE under non-reducing conditions. TNF alpha causes cytolysis of certain transformed cells. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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