Anti-TIM 1 Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

TIM-1

Applications

WB

Reactivity

Human, Rat, (Mouse)

Formulation

Supplied in phosphate-buffered saline with 0.02% Sodium Azide.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Polyclonal

Product form

Liquid

Concentration

1 mg/ml

Isotype

IgG

Recommended dilutions

WB: 1.0 - 2 µg/ml

Molecular weight

Approximately 49 kDa in human uterus tissue lysate.

Protein Length

16

Imunogen

A peptide corresponding to 16 amino acids near the centre of human TIM-1.

Specificitate

This antibody recognises T cell immunoglobulin mucin-1 (TIM-1), which was first identified as the receptor used by hepatitis A for viral entry, it is also known as the hepatitis A virus cellular receptor- HAVCR , TIM -1 also acts as a receptor for other viruses, including Dengue, Ebola and Marburg. TIM-1 is a key cell surface protein that binds TIM-4, leading to T cell proliferation and T helper type 2 (Th2) cytokine production.Two splice variants for human TIM-1 exist; TIM-1a is predominantly expressed in the liver, whilst TIM-1b is expressed in the kidney. Expression of TIM-1 in the kidney is thought to be upregulated in damaged tissue, and is thought to assist healing.TIM-1 polymorphisms are associated with susceptibility to allergy and asthma.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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