Anti-Substance P Antibody [NC1/34]

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µl

Țintă

Substance P

Applications

IHC-P, IHC-Fr, IF

Reactivity

Mammals, Pig, Pigeon, Bichir, Rabbit, Human, Bovine, Guinea Pig, Calanus sp., Crustacea, Cancer sp., Panilurus sp., Homarus sp., Mudpuppy, Lamprey, Crayfish, Zebrafish, Bullfrog, Amphibia, Cockroach, Sheep, Cowbird, Rat, Spadefoot toad, Chicken, Chinchilla, Camel, Beaver, Chinchilla

Formulation

Supplied in 0.05% Thiomersal.

Conjugate

Unconjugated

Host

Rat

Clonality

Monoclonal

Product form

Liquid

Concentration

Lot Specific

Isotype

IgG2a

Recommended dilutions

IHC-Fr: 1:100 - 1:200, IHC-P: 1:100 - 1:200

Purity

Tissue culture supernatant.

Clonă

NC1/34

Imunogen

Substance P conjugated to Bovine Serum Albumin.

Specificitate

This antibody recognises the COOH terminal region of substance P, an eleven amino acid polypeptide neurotransmitter derived by proteolytic cleavage of protachykinin-1. Substance P binds to and activates the neurokinin-1 receptor. Substance P is a highly conserved neurotransmitter expressed throughout the animal kingdom. It is highly expressed in the spinal cord dorsal horn and dorsal root ganglia, but not in the ventral horn (Ribeiro-da-Silva andT Hökfelt 2000). It is also expressed in non-neuronal cells including microglia and other immune cells.Substance P has a role in several physiologic activities such as pain transmission, the vomiting reflex, salivary secretion and smooth muscle contraction (Hökfelt 2004). Rat anti substance P antibody, clone NC1/34 demonstrates ~5% reactivity with eledoisin a neurotransmitter identified in the octopus Genus Eledone. It does not react with Leu or Met-enkephalin, somatostatin or beta-endorphin in tested applications.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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