Anti-pan Cytokeratin Antibody [AE-1/AE-3] (PE)

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Descriere

Specificații

Brand

Antibodies

Mărime

100T

Țintă

pan-Cytokeratin

Applications

Flow Cytometry, IF

Reactivity

Human, Monkey, Bovine, Canine, Rabbit, Mouse, Rat, Chicken

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

PE

Host

Mouse

Clonality

Oligoclonal

Product form

Liquid

Concentration

100 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG1, kappa + IgG1, kappa

Recommended dilutions

Flow Cytometry: 5 µl / million cells or 5 µl / 100 µl whole blood, IF: 1:50-1:100

Molecular weight

40-67 kDa

Clonă

AE-1/AE-3

Imunogen

Human epidermal keratin.

Specificitate

Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 40kDa (CK19). Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE-1/AE-3 is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It has been used to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas.

Storage

Store at 4-8°C. Antibody is stable for 24 months.

Documentație

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