Anti-MUC1 Antibody [rMUC1/960]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

MUC1

Applications

Flow Cytometry, IF, WB, IHC

Reactivity

Human

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

200 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG2b

Recommended dilutions

Flow Cytometry: 0.5-1 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml, IHC: 0.5-1 µg/ml

Molecular weight

265-400 kDa

Light chain

kappa

Clonă

rMUC1/960

Imunogen

Recombinant human MUC1 protein.

Specificitate

This antibody reacts with MUC1, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. The dominant epitope of This antibody involves both amino acids as well as sugar moieties. Neuraminidase treatment destroys the antigen. It is a very good tracer agent in CA15.3 assays. The extracellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 amino acids tandem repeat which can occur 30-100 times per molecule depending on the length of the allele involved. In the vast majority of human carcinomas this protein is up-regulated and poorly glycosylated and appears on the cell surface in a non-polarized fashion.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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