Anti-MUC1 Antibody [MUC1/967]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

MUC1

Applications

WB, Flow Cytometry, IF, IHC

Reactivity

Human

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

200 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG1

Recommended dilutions

WB: 1-2 µg/ml, Flow Cytometry: 0.5-1 µg/million cells, IF: 1-2 µg/ml, IHC-P: 0.25-0.5 µg/ml

Molecular weight

265-400 kDa

Light chain

kappa

Clonă

MUC1/967

Imunogen

Human milk fat globule membranes.

Specificitate

This antibody recognizes full-length MUC1 in a glycosylation-independent manner and can bind to the fully glycosylated protein.The dominant epitope of This antibody is APDTR in the VNTR region. It reacts with the core peptide of the MUC1 protein, which is a member of a family of mucin glycoproteins that are characterized by high carbohydrate content, O-linked oligosaccharides, high molecular weight (200kDa) and an amino acid composition rich in serine, threonine, proline and glycine. The core protein contains a domain of 20 amino-acid tandem repeats that functions as multiple epitopes for the MAb. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This antibody reacts with both normal and malignant epithelia of various tissues including breast and colon.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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