Anti-Estrogen Receptor beta 2 Antibody [57/3]

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Descriere

Specificații

Brand

Antibodies

Mărimi disponibile

50µg · 100µg

Țintă

Estrogen Receptor beta 2

Applications

IHC-P

Reactivity

Human

Formulation

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Isotype

IgG1

Recommended dilutions

IHC-P 1: 1:50 - 1:500

Clonă

57/3

Secvență

CGMKMETLLPEATMEQ

Imunogen

Synthetic peptide sequence CGMKMETLLPEATMEQ from the C terminus of the human estrogen receptor beta 2 isomer.

Specificitate

This antibody recognises the estrogen receptor beta 2 isoform, expressed in cell nuclei of a range of human tissues including the ovary, placenta, testis and vas deferens. No cross-reactivity is seen with estrogen receptor beta 1 isoform. The detection of estrogen (ER) and progesterone (PR) receptors using immunohistochemical staining of formal fixed paraffin embedded (FFPE) tissue, has gradually replaced ligand binding assays (LBA), to become the most common method for the determination of the ER/PR status of breast tumors. Approximately 75% to 80% of breast tumors have estrogen and/or progesterone receptors, and the presence of these receptors helps determine both the patient’s prognosis and the effectiveness of hormonal therapy

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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