Anti-CD10 Antibody [56C6]

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µl

Țintă

CD10

Applications

IHC-P, IHC-Fr

Reactivity

Human, Cynomolgus Monkey

Formulation

Supplied in <0.1% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

Lot Specific

Isotype

IgG1

Recommended dilutions

IHC-Fr: 1:80, IHC-P: 1:80

Purity

Tissue culture supernatant.

Clonă

56C6

Imunogen

Recombinant human CD10.

Specificitate

This antibody recognises human Neprilysin, also known as CD10, Atriopeptidase, Common acute lymphocytic leukemia antigen (CALLA), Enkephalinase, Neutral endopeptidase 24.11, Neutral endopeptidase or Skin fibroblast elastase. CD10 is a 749 amino acid, ~100 kDa single pass type II transmembrane glycoprotein, expressed on a variety of cell types including immature and germinal centre B cells, lymphoblastic leukaemia cells and also on the brush border of kidney epithelial cells.Mutations in the MME gene (encoding CD10) are involved in the development of Charcot-Marie-Tooth disease 2T (CMT2T), a disorder of the peripheral nervous system, demonstrating progerssive peripheral muscle weakness and atrophy. Mutations of the MME gene can also lead to Spinocerebellar ataxia 43 (SCA43) characterized by a progressive loss of gait coordination along with hand, speech and eye coordination. Degeneration of the cerebellum, with variable involvement of the brain stem and spinal cord are apparent in this slow progressive autosomal dominant form of the disease.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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