Anti-CD31 Antibody [2H8] - BSA and Azide free

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Descriere

Specificații

Brand

Antibodies

Mărime

500µg

Țintă

CD31

Applications

Flow Cytometry, IF, Functional Assays

Reactivity

Mouse

Formulation

Supplied in Phosphate Buffered Saline.

Conjugate

Unconjugated

Host

Hamster

Clonality

Monoclonal

Product form

Liquid

Concentration

500 µg/ml

Purification

Protein G affinity chromatography of ascites.

Isotype

IgG

Recommended dilutions

Flow Cytometry: 0.1 µg/ml, Use 5µl of the suggested working dilution to label 100µl of whole blood

Purity

Sterile filtered.

Clonă

2H8

Imunogen

D10.G4.1 cells.

Specificitate

This antibody recognises mouse CD31, also known as Platelet endothelial cell adhesion molecule or PECAM-1. CD31 is a ~130kDa single pass type-1 membrane glycoprotein bearing six C2 Ig-like domains, expressed on all continuous endothelium including arteries, veins and non-sinusoidal capillaries. CD31 is also expressed on all haemopoietic lineages with the exception of the erythroid line. Hamster anti mouse CD31, clone 2H8 effectively inhibits transmigration of activated polymorphonuclear cells and monocytes across the endothelium. In a mouse model for acute peritonitis clone 2H8 blocks acute inflammation. CD31 has also been shown to be critically involved in the sensing of changes in shear stress associated with atherosclerotic lesions and in the associated atherogenesis.

Storage

Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Documentație

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