Anti-CD164 Antibody [67D2]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

CD164

Applications

Flow Cytometry, IP, WB, ICC

Reactivity

Human

Formulation

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein A affinity chromatography of tissue culture supernatant.

Isotype

IgG1

Purity

> 95% (by SDS-PAGE).

Clonă

67D2

Imunogen

Breast tumor cell line T-47D.

Specificitate

This antibody recognises CD164, also known as endolyn, a 160 kDa transmembrne homodimer protein. It is composed of an extracellular region and two O-glycosylated mucin domains (I and II). These two domains are linked by a non-mucin cysteine rich subdomain. CD164 is a member of the sialmucin family and is expressed by CD34+ hematopoietic progenitor cells, activated basophils, erythroid cells as well as various cancerous cells. A key role of CD164 is its involvement in regulating adhesion, migration and proliferation of hematopoietic progenitor cells. Elevated expression of CD164 has been observed in patients with Seazy syndrome which is a primary cutaneous T-cell lymphoma and as such, has been suggested as a potential marker of this disease. This clone CD67D2 recognises the class II epitope which is not sensitive to sialidase, N-glycanase and O-sialglycoprotease of CD164. This clones has been used in flow cytometry to examine CD164 upregulation in CD203c+ activated basophils.

Storage

Store undiluted at 4°C. Do not freeze!

Documentație

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