Anti-CD11a Antibody [MEM-25] (APC)

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Descriere

Specificații

Brand

Antibodies

Mărime

100T

Țintă

CD11a

Applications

Flow Cytometry

Reactivity

Human

Formulation

Supplied in Phosphate Buffered Saline with 0.2% BSA and <0.1% Sodium Azide.

Conjugate

APC

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

Lot Specific

Purification

Size exclusion chromatography of tissue culture supernatant.

Isotype

IgG1

Recommended dilutions

Flow Cytometry: Neat, Use 10µl of the undiluted product to label 1x10⁶ cells in 100µl

Purity

> 95% (by SDS-PAGE).

Clonă

MEM-25

Imunogen

Leucocytes from a patient suffering from a LGL-type leukemia.

Specificitate

This antibody recognises the integrin alphaL subunit, a 170-180 kDa type I transmembrane glycoprotein that associates with CD18 to form the leucocyte function-associated antigen-1, an alphaLbeta2 integrin expressed at the surface of all human leukocyte.LFA-1 is a receptor for ICAMs, JAM-1 and F11R. Its interaction with endothelial ligands, such as ICAM-1 and JAM-1 is responsible for leukocyte arrest and extravasation. In addition to its role in leukocyte adhesion and transmigration, LFA-1 is involved in T cell differentiation (Verma et al. 2016, Verman and Kelleher 2017) and is required for the effective lysis of infected cells by cytotoxic T cells (Anikeeva et al. 2005, Pontes Ferreira et al. 2017). LFA-1 also contributes to NK cell cytotoxicity and participates to the clearance of apoptotic neutrophils by macrophages (Kristóf et al. 2013). The interaction of LFA-1 with ICAM-1 is the target of Lifitegrast, a drug approved for the treatment of Dry Eye Disease. Mouse anti Human CD11 antibody, clone MEM-25 inhibits the cytotoxic activity of NK cells.

Storage

Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light.

Documentație

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