Recombinant Yellow Fever Virus NS1 Protein

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Specificații

Brand

Antibodies

Mărime

100µg

Țintă

Yellow Fever Virus NS1 Protein

Applications

ELISA

Formulation

Supplied in Dulbecco's, pH osphate Buffered Saline.

Product form

Liquid

Concentration

Lot Specific

Purity

> 95% (by SDS-PAGE).

Expression system

HEK293

Nature

Recombinant

Protein species

Viral

Specificitate

Recombinant yellow fever virus NS1 protein is produced as a hexamer in the human 293 cell line. This product has been purified and retains its native folding state and post-translational modifications providing optimal antigenicity. Research indicates that the hexamer is the biologically active form of the NS1 antigen and therefore involved in the pathogenesis of yellow fever virus (YFV).Yellow fever virus belongs to the Flaviviridae family and like closely related viruses, such as West Nile virus, is an abovirus utilizing various mosquito species as vectors. YFV appears to be restricted naturally to human and other primates but can be experimentally induced in other mammalian species. In recent years an increasing number cases of YFV infection have been reported.Originating in Africa, YFV has been introduced to tropical regions of South America and periodic outbreaks have historically occurred in both Europe and North America. According to the World Health Organization (WHO), it has been estimated that approximately 200,000 people contract YFV annually with around 30,000 cases resulting in fatality, the majority of these on the African continent.This product may be used in research to investigate vaccine development (Bonaldo, M.C. et al. 2014) or in research into the development of assays to detect YFV infection (Ding, X.X,et al. 2014).

Storage

Short term: Store undiluted -20°C. Long term: Store undiluted at -70°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.Should this product contain a precipitate we recommend microcentrifugation before use.

Documentație

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