Native Human Thyroglobulin Protein

Pe scurt

Specificații

Brand

Antibodies

Mărime

1mg

Țintă

Thyroglobulin

Applications

ELISA

Formulation

Supplied in Phosphate Buffered Saline.

Product form

Liquid

Concentration

1 mg/ml

Molecular weight

660 kDa by chromatography and electrophoresis, under certain conditions the 330 kDa subunit may be observed.

Purity

> 98% (by SDS-PAGE).

Nature

Native

Protein species

Human

Source

Human thyroid glands.

Specificitate

Purified Human Thyroglobulin is derived from human thyroid glands and is the precursor of thyroxine (T3) and triiodothyronine (T4). Thyroglobulin is a 2768 amino acid secreted glycoprotein with a 19 aa N-terminal signal peptide, made within and targeted to the thyroid.Mutations of the TG gene may lead to the development of Thyroid dyshormonogenesis 3 (TDH3) a condition presenting with predominant goiters on the majority of patients and may lead to varying degrees of neurologic and intellectual defects. Variations in the TG gene may also result in increased susceptibility to the development of Autoimmune thyroid disease 3 (AITD3), an autoimmune disorder comprised of two related diseases of the thyroid: Graves disease and Hashimoto thyroditis (Caturegli et al. 2014).

Storage

Store undiluted at -20°C only, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Documentație

• Fișă tehnică (PDF)se deschide pe site-ul producătorului