Anti-ZAP70 Antibody [ZAP70/528 + 2F3.2]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

ZAP70

Applications

IHC-P

Reactivity

Human

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Oligoclonal

Product form

Liquid

Concentration

200 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG2a, kappa + IgG2a, kappa

Recommended dilutions

IHC-P: 1-2 µg/ml

Molecular weight

70 kDa

Clonă

ZAP70/528 + 2F3.2

Imunogen

Clone ZAP70/528: Recombinant full-length human ZAP70 protein. Clone 2F3.2: Recombinant ZAP-70 protein including residues 1-254 and encompassing SH2 domains of human ZAP70.

Specificitate

ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells.Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well.Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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