Anti-Von Willebrand Factor Antibody [E01-1C8] (Biotin)

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

Von Willebrand Factor

Applications

ELISA

Reactivity

Human

Formulation

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Conjugate

Biotin

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

100 µg/ml

Purification

Protein G affinity chromatography of tissue culture supernatant.

Isotype

IgG2b

Recommended dilutions

ELISA: 1 µg/ml.

Clonă

E01-1C8

Imunogen

CHO derived recombinant full length human vWF (Met1-Lys2813).

Specificitate

This antibody recognises von Willebrand factor (vWF) a multifunctional glycoprotein that plays essential roles in primary and secondary homeostasis, mediates platelet adhesion and is a carrier of coagulation factor VIII. vWF is present in blood plasma, the subendothelial matrix, platelet granules (a granules) and endothelial cells. In endothelial cells, the vWF is stored in mature Weibel-Palade bodies before it is secreted into the plasma. vWF plasma levels are influenced by genetic, pathological, hormonal and environmental interactions. Upon vascular injury, vWF mediates the anchoring of platelets to the subendothelium leading to the formation of a platelet plug and the arrest of bleeding. Due to its acute release by the activated epithelium, vWF has been considered a marker of inflammation in various pathologies. However there is evidence that vWF is able to play a direct role in inflammation by recruiting leukokcytes to sites of inflammation. The biotinylated Mouse anti Human vWF antibody, clone E01-1C8 (MCA6289B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human vWF antibody, clone C01-1F2 (MCA6288GA) as the capture antibody.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Documentație

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