Anti-TSLP Antibody [H03-5E12]

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

TSLP

Applications

ELISA

Reactivity

Human

Formulation

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein G affinity chromatography of tissue culture supernatant.

Isotype

IgG1

Recommended dilutions

ELISA: 1 µg/ml.

Clonă

H03-5E12

Imunogen

E. coli derived recombinant full length human TSLP (Tyr29-Gln159).

Specificitate

This antibody recognises thymic stromal lymphopoietin (TSLP), a member of the interleukin-2 (IL-2) cytokine family and an IL-7-like cytokine. TSLP plays a role in pathophysiological immunity-related functions. Specifically, TSLP is implicated in allergic reaction, infection, cancer and autoimmunity. During allergic inflammation, the primary producers of TSLP are epithelial cells, keratinocytes, mast cells, smooth muscle cells, dendritic cells and trophoblasts (Takai 2012). TSLP is a ligand of the TSLP receptor (TSLPR), which is expressed by a variety of hematopoietic cell populations and some hematopoietic cells such as epithelial cells. Upon binding of TSLP to TSLPR various signaling pathways can be activated including JAK, STAT, Src kinases and PI3K. Under physiological conditions, induction of these pathways can promote homeostatic polyclonal expansion of T cells in the absence of foreign antigens and drive differentiation of inducible Tregs. The purified Mouse anti Human TSLP antibody, clone H03-5E12 (MCA6284GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human TSLP antibody, clone D01-2E2 (MCA6285B) as the detection antibody.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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