Anti-Tropomyosin 1 alpha Antibody [TPM1/4510] - BSA and Azide free

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

Tropomyosin 1 (alpha)

Applications

IHC-P

Reactivity

Human

Formulation

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein A/G chromatography.

Isotype

IgG1

Recommended dilutions

IHC: 1-2 µg/ml

Molecular weight

35 - 45 kDa

Clonă

TPM1/4510

Imunogen

Recombinant full-length TPM1 protein.

Specificitate

Tropomyosins are a group of structural proteins. Tropomyosins are present in virtually all eukaryotic cells, both muscle and non-muscle, where they bind actin filaments and function to modulate Actin-myosin interaction and stabilize actin filament structure. Tropomyosin is encoded by the TPM1 gene, which maps to human chromosome 15q22.2 and undergoes alternative splicing to generate at least four isoforms, including skeletal muscle (isoform 1), smooth muscle (isoform 2), fibroblast/TM3 (isoform 3) and isoform 4. Tropomyosin b is encoded by the TPM2 gene, which maps to human chromosome 9p13.3 and undergoes alternative splicing to generate three isoforms, including skeletal muscle (isoform 1), non-muscle/fibroblast TM36/epithelial TMe1 (isoform 2) and non-muscle (isoform 3). Troponin I binds Tropomyosin at a specific region and the association of Tropomyosin-Troponin with actin filaments may increase the rigidity of actin filaments. Tropomyosin also interacts with caldesmon to regulate smooth muscle contraction.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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