Anti-Transferrin Antibody [HTF-14]

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Descriere

Specificații

Brand

Antibodies

Mărime

200µg

Țintă

Transferrin

Applications

ELISA, WB, IF, Functional Assays

Reactivity

Human, Pig, Rabbit, Rat

Formulation

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein A affinity chromatography of ascites.

Isotype

IgG1

Molecular weight

Approximately 77 kDa under reducing conditions in human plasma.

Cross reactivity

This antibody does not cross react with Sheep, Bovine, Dog, or Horse

Clonă

HTF-14

Imunogen

Purified porcine transferrin.

Specificitate

This antibody recognises the N-terminal domain of human transferrin and has been shown to block binding of transferrin to the transferrin receptor (CD71). Clone HTF-14 is not able to recognize receptor bound transferrin. Clone HTF-14 recognises a conformational epitope in a loop of the N lobe of transferrin involving the critical Lys-144 residue, also essential for binding of the N lobe to the transferrin receptor Transferrin is a 77 kDa plasma protein synthesized by the liver involved with the transport of iron. Each transferrin molecule has two domains, both with facility to carry 2 ferric ions. The iron/transferrin complex is essential for hemoglobin synthesis and certain types of cell division.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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