Anti-Src Antibody [4F10B5]

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Descriere

Specificații

Brand

Antibodies

Mărime

50µl

Țintă

Src

Applications

WB

Reactivity

Human, Rat

Formulation

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide and 50% Glycerol,.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Monoclonal

Product form

Liquid

Concentration

Lot Specific

Isotype

IgG

Recommended dilutions

WB: 1:500-1:2,000

Clonă

4F10B5

Imunogen

Recombinant protein of human SRC.

Specificitate

This antibody recognises proto-oncogene tyrosine-protein kinase Src, also known as Src1, p60-Src and c-Src. c-Src is a ubiquitously-expressed cytoplasmic tyrosine kinase, important for regulating diverse cellular functions. c-Src was the first oncogene to be identified, over-expressed and abnormally activated in cancer cells, and is the cellular counterpart of v-Src, a cancer-causing gene found in the Rous sarcoma virus. Src functions as a complex molecular switch, which can self-modulate its activity in response to specific signals. This is achieved by a reciprocally regulatory mechanism involving Tyr416 and Tyr527, changing the tertiary structure of Src and controlling access to its active site.

Storage

Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Documentație

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