Anti-SOS1 Antibody [SOS-01]

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

SOS1

Applications

WB, ELISA, IF

Reactivity

Human, Mouse

Formulation

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein A affinity chromatography of tissue culture supernatant.

Isotype

IgG1

Recommended dilutions

WB: 1 µg/ml

Molecular weight

Approximately 150 kDa in K562 and RAJI human cell lysates under reducing conditions.

Clonă

SOS-01

Secvență

THPSMHRDGPPLLENAHSS

Imunogen

Synthetic peptide sequence THPSMHRDGPPLLENAHSS of human SOS1.

Specificitate

This antibody recognises SOS1 (son of sevenless homolog 1), a ubiquitously expressed 1333 amino acid ~150 kDa intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases.Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 , and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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