Anti-SERBP1 Antibody [SERBP1/3491]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

SERBP1

Applications

WB, IHC-P

Reactivity

Human

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

200 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG1

Recommended dilutions

WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Molecular weight

60 kDa

Light chain

kappa

Clonă

SERBP1/3491

Imunogen

Recombinant fragment, around amino acids 3-139, of human SERBP1 protein. The exact sequence is proprietary.

Specificitate

SERBP1 is a membrane-associated protein that localizes to the nucleus, the perinuclear region of the cytoplasm and the plasma membrane. It is believed to play a role in the regulation of mRNA stability, as it specifically binds to the CRS (cyclic nucleotide-responsive sequence) motif of the PAI-1 mRNA and acts to stabilize the mRNA and regulate its expression. In addition, SERBP1 interacts with Mi2-s antiapoptotic action in ovarian cell types. SERBP1 is overexpressed in ovarian cancer, suggesting a possible role in tumorigenesis and tumor metastasis.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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