Anti-S1A5 Antibody [S100A5/7474]

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

S1A5

Applications

IHC-P

Reactivity

Human

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

200 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG2a

Recommended dilutions

IHC: 1-2 µg/ml

Molecular weight

11 kDa

Light chain

kappa

Clonă

S100A5/7474

Imunogen

Recombinant fragment (around Amino Acids 1-92) of human S100A5 protein. The exact sequence is proprietary.

Specificitate

The S-100 proteins are small calcium-binding proteins which display different expression patterns in human tissues. Some S-100 proteins are associated with tumor development and the metastatic behavior of tumors. S-100A5 (S100 calcium binding protein A5) is a 92 amino acid protein that belongs to the S-100 family. Containing two EF-hand domains, S-100A5 binds calcium, zinc and copper. One subunit can simultaneously bind two calcium ions or two copper ions plus one zinc ion. Calcium and copper ions compete for the same binding sites on the S-100A5 protein. The S-100A5 protein is expressed in very restricted regions of the adult brain. The S-100A5 gene is conserved in chimpanzee, dog, cow, mouse and rat, and maps to human chromosome 1q21.3. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. Due to the clustered organization of the S-100 proteins a new logical nomenclature based on their physical arrangement on the chromosome has been described, with S-100A1 being closest to the telomere and S-100A9 being closest to the centromere.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

• Fișă tehnică (PDF)se deschide pe site-ul producătorului