Anti-Ryanodine Receptor Antibody [RYR.1 (G-1)]

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Descriere

Specificații

Brand

Antibodies

Mărime

50µg

Țintă

Ryanodine Receptor

Applications

Flow Cytometry, ELISA, IHC-Fr, WB, IF

Reactivity

Human, Mouse, Dog, Bovine, Pig, Rat

Formulation

Supplied in Phosphate Buffered Saline with 0.01% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

500 µg/ml

Isotype

IgG2b

Recommended dilutions

ELISA: 1:1,000, Flow Cytometry: 1:500, WB: 1:100, IF 1: 1:100, IHC-Fr: 1:100

Clonă

RYR.1 (G-1)

Imunogen

Short synthetic polypeptide corresponding to the C-terminus domain of the ryanodine receptor.

Specificitate

This antibody recognises the human ryanodine receptor 1, also known as Skeletal muscle calcium release channel or skeletal muscle ryanodine receptor. Ryanodine receptor 1 is a is a large 5038 amino acid ~500 kDa multi pass sarcoplamic reticulum associated transmembrane protein containing three B30.2/SPRY domains and five MIR domains. recognises an epitope within the C-terminal cytoplasmic domain of the ryanodine receptor (UniProt: P21817). Ryanodine receptors have been shown to play critical roles in the intracellular Ca2+ signaling occurring during cell activation in muscle cells and non-muscle cells. Mouse anti Human Ryanodine Receptor antibody, clone RYR-1 reacts with ryanodine receptor isolated from a variety of cell types (e.g. lymphocytes, macrophages, granulocytes, fibroblasts, epithelial, endothelial cells, skeletal muscle, cardiac muscle and brain tissues). Defects in the ryanodine receptor 1 gene are associated with malignant hyperthermia , central core disease of muscle and certain congential myopathies.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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