Anti-Rabies Virus Glycoprotein Antibody [1C5]

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Descriere

Specificații

Brand

Antibodies

Mărime

200µg

Țintă

Rabies Virus Glycoprotein

Applications

Functional Assays, ELISA, IHC-Fr, IF

Reactivity

Viral

Formulation

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein A affinity chromatography of tissue culture supernatant.

Isotype

IgG2a

Clonă

1C5

Imunogen

Purified rabies virus.

Specificitate

This antibody recognises the glycoprotein of rabies virus, a Lyssavirus that causes rabies in mammals. The virus is found in the saliva of infected animals and is mostly spread though bites. The virus then travels though the peripheral nervous system to the central nervous system. Once it reaches the brain it causes acute encephalitis. Symptoms include paralysis, cerebral dysfunction, anxiety, insomnia, confusion, anger, paranoia, terror and hallucination. The production of a large amount of saliva, the inability to speak or swallow and associated hydrophobia is also common in the later stages of the disease. The time between exposure to the virus and onset of symptoms can range from about 2 weeks to several months. Once symptoms appear, death is virtually inevitable. However, the disease can be effectively treated by post-exposure prophylaxis, through vaccination, provided this is done as soon as possible.recognises the purified glycoprotein of the rabies virus as well as the native virus. It has been shown to react with intact infected BHK cells and has therapeutic effect on infected mice. The antibody has virus-neutralising activity with several rabies virus strains such as CVS, Lagos bat, Mokola, Flury LEP and Duvenhage.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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