Anti-Properdin / PFC Antibody [062-27.8.1 (10-18)]

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

Properdin/PFC

Applications

Flow Cytometry, ELISA, IHC-Fr, WB, Functional Assays

Reactivity

Human

Formulation

Supplied in Borate Buffered Saline with <0.1% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein A affinity chromatography of ascites.

Isotype

IgG1

Recommended dilutions

Flow Cytometry: 1:1,000, IHC-Fr: 1:1,000

Clonă

062-27.8.1 (10-18)

Imunogen

Native purified factor P from human serum.

Specificitate

This antibody recognises human factor P, a 53 kDa glycosylated protein present in blood serum. Factor P binds to microbial surfaces and binds and stabilizes the complement component 3- and complement component 5-convertase enzyme complexes. C3b then acts as an opsonin or initiates the complement pathway again creating a positive feedback loop which acts only on the bacterial cell, leaving the host cells unharmed. Deficiency of factor P makes the host more susceptible to bacterial infections, particularly to Neisseria species and meningococcal infections. Mouse anti Human Factor P antibody, clone 10-18 is reported to inhibit the function of factor P. Removal of sodium azide is recommended prior to use in functional assays.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

• Fișă tehnică (PDF)se deschide pe site-ul producătorului