Anti-PD-L1 Antibody [29E.2A3] (FITC)

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Descriere

Specificații

Brand

Antibodies

Mărime

100T

Țintă

PD-L1

Applications

Flow Cytometry

Reactivity

Human, Primate

Formulation

Supplied in Phosphate Buffered Saline with 0.2% BSA and <0.1% Sodium Azide.

Conjugate

FITC

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

Lot Specific

Purification

Protein A affinity chromatography of tissue culture supernatant.

Isotype

IgG2b

Recommended dilutions

Flow Cytometry: Neat, Use 4ul of the suggested working dilution to label 1x10⁶ cells in 100µl

Purity

> 95% (by SDS-PAGE).

Clonă

29E.2A3

Imunogen

Full-length human CD274.

Specificitate

This antibody recognises human CD274, also known as B7-H1 and PD-1L, a cell surface glycoprotein which is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T cells, B cells, endothelial cells and epithelial cells in response to interferons alpha, beta and gamma.CD274 is reported to possess dual functions; inhibition of activated effector T cells and co-stimulation of naïve T cells. CD274 inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. CD274 has also been shown to co-stimulate early T cell priming and differentiation.Deregulated CD274 function has been reported in chronic viral and intracellular bacterial infection, as well as in many autoimmune diseases and cancers.

Storage

Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light.

Documentație

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