Anti-PARP1 Antibody [A6.4.12]

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

PARP1

Applications

WB, IHC-P, IP, IHC-Fr, ELISA, IF

Reactivity

Human, Hamster, Mouse, Drosophila, Xenopus, Rat

Formulation

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein A affinity chromatography of tissue culture supernatant.

Isotype

IgG1

Recommended dilutions

WB: 1:1,000-1:5,000

Clonă

A6.4.12

Imunogen

Human PARP-1.

Specificitate

This antibody recognises poly (ADP-ribose) polymerase 1 (PARP-1), a ~116 kDa nuclear enzyme, cleaved during apoptosis. PARP-1, a caretaker enzyme, is involved in DNA damage repair , plays roles in diabetes pathophysiology and tumour proliferation (Rosado et al 2013.).As well as protecting cells from genomic instability, PARP-1 is involved in the development of both inflammatory and immune responses, and cell death by apoptosis and necrosis (Erdélyi et al. 2005). Mouse anti poly(ADP-ribose) polymerase 1 antibody, clone A6.4.12, targets PARP-1, an enzyme which represents a promising target for new developments in therapeutic treatment of immune mediated diseases. PARP-1 has considerable potential for delivering selective tumour cell killing while sparing normal cells.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

• Fișă tehnică (PDF)se deschide pe site-ul producătorului