Anti-Parathyroid Hormone Antibody [BGN/1F8]

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Descriere

Specificații

Brand

Antibodies

Mărime

200µg

Țintă

Parathyroid Hormone

Applications

ELISA, IHC-Fr, IHC-P

Reactivity

Human, Rat, (Mouse)

Formulation

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein A affinity chromatography of tissue culture supernatant.

Isotype

IgG1

Recommended dilutions

ELISA: 1:2 000 - 1:20 000

Protein Length

34

Clonă

BGN/1F8

Secvență

MIPAKDMAKVMIVMLAICFLTKSDGKSVKKRSVS

Imunogen

Synthetic peptide corresponding to amino acids 1-34 of mature PTH conjugated to a proprietary carrier molecule.

Aminoacizi

aa 1 - 34

Specificitate

This antibody recognises human parathyroid hormone (PTH) also known as Parathyrin. PTH is a hormone produced by the parathyroid gland responsible for the regulation of calcium and phosphorus concentrations in extracellular fluid (Brown 1983).Human parathyroid hormone is produced in the parathyroid gland as a 115 amino acid single chain polypeptide, bearing a 25 amino acid signal peptide, a 6 amino acid pro-peptide sequence and an 84 amino acid mature hormone. Defects in the PTH gene are a cause of familial isolated hypoparathyroidism (FIH), a condition characterized by hypocalcemia and hyperphosphatemia owing to levels of parathyroid hormone being insufficient to maintain extracellular calcium concentrations within normal parameters. Clinical features of FIH include cramps, seizures and tetany. More rarely, hypoparathyroidism like disease, Pseudohypothyroidism (PHP1A) may be caused by mutations in the GNAS gene or defects in the PTHR1 gene (Cohen 2002) leading to Jansen metaphyseal chondrodysplasia (JMC), conditions where end organ resistance to PTH function exists.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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