Anti-p63 Antibody

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

p63

Applications

WB, ELISA 

Reactivity

Human, Mouse

Formulation

Supplied in Phosphate Buffered Saline with 0.1% BSA and 0.1% Sodium Azide.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Polyclonal

Product form

Liquid

Concentration

1 mg/ml

Isotype

IgG

Recommended dilutions

ELISA: 1:100,000, WB: 1:1,000

Molecular weight

Approximately 75 kDa in mouse lung and human tumour cell line K562 (protein degredation is as expected).

Protein Length

19

Secvență

C-NFDMDARRNKQQRIKEEGE

Imunogen

Synthetic peptide sequence C-NFDMDARRNKQQRIKEEGE corresponding to amino acids 662-680 within the C-terminus of p63.

Aminoacizi

aa 662 - 680

Specificitate

This antibody recognises an epitope within the C-terminal (CT) region of tumour protein p63, otherwise known as tumour protein p73-like (p73L), a widely expressed nuclear protein and homologue of tumour suppressor p53, which acts as a sequence-specific DNA binding transcriptional activator/repressor. p63, vital for the development of the prostate and selectively expressed by normal prostate basal cells, has been shown to be a promising complementary basal cell specific marker to High Molecular Weight-Cytokeratin (HMW-CK), for the differential diagnosis of benign prostatic lesions and prostatic carcinoma. Rabbit anti p63 antibody is reported as suitable for use in immunocytochemistry.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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